T-Cell Development: T-cell lineage commitment revisited
نویسندگان
چکیده
منابع مشابه
T-Cell Development: T-cell lineage commitment revisited
Years of controversy about the lineage relationship between alpha beta and gamma delta T cells may at last have been resolved: it now appears that most T cells derive from an identical T-lineage committed precursor.
متن کاملT cell lineage commitment: identity and renunciation.
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterward. This process involves three levels of regulatory change, in which the cells' intrinsic transcriptional regulatory factors, expression of signaling receptors (e.g., Notch1), and expression of distinct homi...
متن کاملT cell lineage commitment: identity and renunciation1
Precursors undertaking T-cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterwards. This process involves three levels of regulatory change, in which the cells’ intrinsic transcriptional regulatory factors, expression of signaling receptors like Notch1, and expression of distinct homing...
متن کاملThreshold of pre-T-cell-receptor surface expression is associated with αβ T-cell lineage commitment
Results: We have used a sensitive immunofluorescence technique to reveal the surface-expression profile of the pre-TCR on immature thymocyte subsets. We show that early pre-T cells (CD25+CD44–) can be subdivided on the basis of the level of surface pre-TCR expression. Detectable surface pre-TCR expression identified a rapidly cycling population of early pre-T cells which had successfully underg...
متن کاملT-cell lineage commitment and cytokine responses of thymic progenitors.
The earliest steps of intrathymic differentiation recently have been elucidated. It has been reported that both CD4lo (CD44+ CD25- c-kit+ CD3- CD4lo CD8-) and pro-T cells (CD44+ CD25+ c-kit+ CD3- CD4- CD8-, representing the next step in maturation) exhibit germline T-cell receptor beta and gamma loci, suggesting that neither population is exclusively committed to the T-cell lineage. Several gro...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1995
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(95)00164-3